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Studies & clinical trials

What each medicine is approved for, what has been tested in people, and what has only been seen in the lab. Every study links to its source.

Medically reviewed by Dr Jane Smith, PharmD · Last reviewed October 2026

Evidence levels: Approved use Clinical trials in people Lab & animal studies only Case reports only

Ivermectin

An antiparasitic medicine on the WHO Essential Medicines List. Its discovery earned the 2015 Nobel Prize in Medicine.

Approved use
  • Strongyloidiasis (intestinal threadworm) — tablets
  • Onchocerciasis (river blindness) — tablets
  • Head lice and rosacea — creams and lotions applied to the skin

COVID-19

Clinical trials in people

Large randomised trials found no meaningful benefit on hospitalisation or recovery.

2022 No benefit found Randomised controlled trial · 1,358 people TOGETHER trial: no lower rate of hospitalisation or prolonged emergency care than placebo. Read the source on PubMed ↗ 2022 No benefit found Randomised controlled trial · 1,591 people ACTIV-6: no shorter time to recovery than placebo at 400 µg/kg for 3 days. Read the source on PubMed ↗ 2022 No benefit found Randomised controlled trial · 1,323 people COVID-OUT: ivermectin did not prevent severe COVID-19. Read the source on PubMed ↗ 2024 Mixed result Randomised controlled trial · 2,157 people PRINCIPLE: recovery about 2 days sooner on average, but no reduction in hospital admissions or deaths. Read the source on PubMed ↗

Ongoing trials of Ivermectin live from ClinicalTrials.gov

Search all trials on ClinicalTrials.gov ↗

Mebendazole

A widely used treatment for intestinal worms, on the WHO Essential Medicines List.

Approved use
  • Pinworm, roundworm, whipworm and hookworm infections

Other cancers

Lab & animal studies only

Studied in cell and animal models of several cancers; human evidence is limited to small early trials and case reports.

Ongoing trials of Mebendazole live from ClinicalTrials.gov

Search all trials on ClinicalTrials.gov ↗

Fenbendazole

A veterinary dewormer (dogs, cats, livestock). It is not approved for use in people anywhere.

Approved use
  • Veterinary use only: intestinal worms in animals

Cancer

Lab & animal studies only

Lab studies show effects on cancer cells. There are no completed clinical trials in people, and cases of liver injury have been reported in people taking it on their own.

2018 Early research Lab study Disrupts microtubules and causes death of human lung cancer cells in the lab. Read the source on PubMed ↗ 2021 Safety signal Case report · 1 patient Liver injury in a patient with lung cancer who self-administered fenbendazole; it resolved after stopping. Read the source on PubMed ↗

Ongoing trials of Fenbendazole live from ClinicalTrials.gov

Search all trials on ClinicalTrials.gov ↗

Questions to ask your doctor

  1. Is this medicine right for my condition, and what does the evidence show for someone like me?
  2. Could it interact with my other medicines or supplements?
  3. What dose and duration would you recommend, and how should we monitor it (for example, liver tests)?
  4. What side effects should make me stop and call you?
  5. Is there a clinical trial I could join?

This page summarises published research for general information. It is not medical advice and does not suggest any medicine treats a condition it is not approved for. Talk to your doctor before starting, stopping or changing any medicine.